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53BP1: a DSB escort
53BP1 is an enigmatic DNA damage response factor that gained prominence because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient cancers. Recent studies have elevated 53BP1 from its modest status of (yet another) DNA damage factor to master regulator of double-strand b...
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| Udgivet i: | Genes Dev |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6938671/ https://ncbi.nlm.nih.gov/pubmed/31896689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.333237.119 |
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