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53BP1: a DSB escort
53BP1 is an enigmatic DNA damage response factor that gained prominence because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient cancers. Recent studies have elevated 53BP1 from its modest status of (yet another) DNA damage factor to master regulator of double-strand b...
Shranjeno v:
| izdano v: | Genes Dev |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6938671/ https://ncbi.nlm.nih.gov/pubmed/31896689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.333237.119 |
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