Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

An increasingly appreciated conundrum in the discovery of antibody drug conjugates (ADCs) is that an antibody that was selected primarily for strong binding to its cancer target may not serve as an optimal ADC. In this study, we performed mechanistic cell-based experiments to determine the correlati...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zwaagstra, John C., Sulea, Traian, Baardsnes, Jason, Radinovic, Stevo, Cepero-Donates, Yuneivy, Robert, Alma, O’Connor-McCourt, Maureen D., Tikhomirov, Ilia A., Jaramillo, Maria Luz.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938348/
https://ncbi.nlm.nih.gov/pubmed/31891584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226593
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