Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Sulea, Traian, Rohani, Nazanin, Baardsnes, Jason, Corbeil, Christopher R., Deprez, Christophe, Cepero-Donates, Yuneivy, Robert, Alma, Schrag, Joseph D., Parat, Marie, Duchesne, Mélanie, Jaramillo, Maria L., Purisima, Enrico O., Zwaagstra, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927761/
https://ncbi.nlm.nih.gov/pubmed/31777319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1682866
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