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Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

The Rho and Ras pathways play vital roles in cell growth, division and motility. Cross-talk between the pathways amplifies their roles in cell proliferation and motility and its dysregulation is involved in disease pathogenesis. One important interaction for cross-talk occurs between p120RasGAP (RAS...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jaber Chehayeb, Rachel, Stiegler, Amy L., Boggon, Titus J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938330/
https://ncbi.nlm.nih.gov/pubmed/31891593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226113
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