Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response

The unfolded protein response (UPR) senses defects in the endoplasmic reticulum (ER) and orchestrates a complex program of adaptive cellular remodeling. Increasing evidence suggests an important relationship between lipid homeostasis and the UPR. Defects in the ER membrane induce the UPR, and the UP...

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Pubblicato in:Mol Biol Cell
Autori principali: Micoogullari, Yagmur, Basu, Sankha S., Ang, Jessie, Weisshaar, Nina, Schmitt, Nicholas D., Abdelmoula, Walid M., Lopez, Begona, Agar, Jeffrey N., Agar, Nathalie, Hanna, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938273/
https://ncbi.nlm.nih.gov/pubmed/31746669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-07-0392
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