Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production

Processing of amyloid precursor protein (APP) by the β-secretase BACE1 is the initial step of the amyloidogenic pathway to generate amyloid-β (Aβ). Although newly synthesized BACE1 and APP are transported along the secretory pathway, it is not known whether BACE1 and APP share the same post-Golgi tr...

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Published in:Mol Biol Cell
Main Authors: Tan, Jing Zhi A., Fourriere, Lou, Wang, Jingqi, Perez, Franck, Boncompain, Gaelle, Gleeson, Paul A.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938271/
https://ncbi.nlm.nih.gov/pubmed/31746668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-09-0487
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