Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Transcripts of noxious stimulus-detecting TrpA1 channels are alternatively spliced. Despite the importance of nociception for survival, the in vivo significance of expressing different TrpA1 isoforms is largely unknown. Here we develop a novel genetic approach to generate Drosophila knock-in strains...

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Udgivet i:Curr Biol
Main Authors: Gu, Pengyu, Gong, Jiaxin, Shang, Ye, Wang, Fei, Ruppell, Kendra T., Ma, Zhiguo, Sheehan, Amy E., Freeman, Marc R., Xiang, Yang
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938258/
https://ncbi.nlm.nih.gov/pubmed/31735672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.09.070
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