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Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments
Monocarboxylate transporter 4 (MCT4) is an H(+)-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion. Intriguingly, at 30–40 mm, the repo...
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| Izdano u: | J Biol Chem |
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| Glavni autori: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6937558/ https://ncbi.nlm.nih.gov/pubmed/31719150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009093 |
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