Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

Monocarboxylate transporter 4 (MCT4) is an H(+)-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion. Intriguingly, at 30–40 mm, the repo...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Contreras-Baeza, Yasna, Sandoval, Pamela Y., Alarcón, Romina, Galaz, Alex, Cortés-Molina, Francisca, Alegría, Karin, Baeza-Lehnert, Felipe, Arce-Molina, Robinson, Guequén, Anita, Flores, Carlos A., San Martín, Alejandro, Barros, L. Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937558/
https://ncbi.nlm.nih.gov/pubmed/31719150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009093
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