Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

Monocarboxylate transporter 4 (MCT4) is an H(+)-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion. Intriguingly, at 30–40 mm, the repo...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Contreras-Baeza, Yasna, Sandoval, Pamela Y., Alarcón, Romina, Galaz, Alex, Cortés-Molina, Francisca, Alegría, Karin, Baeza-Lehnert, Felipe, Arce-Molina, Robinson, Guequén, Anita, Flores, Carlos A., San Martín, Alejandro, Barros, L. Felipe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937558/
https://ncbi.nlm.nih.gov/pubmed/31719150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009093
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