Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

Monocarboxylate transporter 4 (MCT4) is an H(+)-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion. Intriguingly, at 30–40 mm, the repo...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Contreras-Baeza, Yasna, Sandoval, Pamela Y., Alarcón, Romina, Galaz, Alex, Cortés-Molina, Francisca, Alegría, Karin, Baeza-Lehnert, Felipe, Arce-Molina, Robinson, Guequén, Anita, Flores, Carlos A., San Martín, Alejandro, Barros, L. Felipe
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937558/
https://ncbi.nlm.nih.gov/pubmed/31719150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009093
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