Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

Resistance of breast cancer to human epidermal growth factor receptor 2 (HER2) inhibitors involves reprogramming of the kinome through HER2/HER3 signaling via the activation of multiple tyrosine kinases and transcriptional upregulation. The heterogeneity of induced kinases prevents kinase targeting...

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Udgivet i:Oncogene
Main Authors: Sun, Bowen, Mason, Seth, Wilson, Robert C., Hazard, Starr E., Wang, Yubao, Fang, Rong, Wang, Qiwei, Yeh, Elizabeth S., Yang, Meixiang, Roberts, Thomas M., Zhao, Jean J., Wang, Qi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937212/
https://ncbi.nlm.nih.gov/pubmed/31462705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0953-9
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