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Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding
The heterodimeric receptor tyrosine kinase complex formed by HER2 and HER3 can act as an oncogenic driver and is also responsible for rescuing a large number of cancers from a diverse set of targeted therapies. Current inhibitors of these proteins, particularly HER2, have dramatically improved patie...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5069157/ https://ncbi.nlm.nih.gov/pubmed/27595329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2171 |
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