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Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding

The heterodimeric receptor tyrosine kinase complex formed by HER2 and HER3 can act as an oncogenic driver and is also responsible for rescuing a large number of cancers from a diverse set of targeted therapies. Current inhibitors of these proteins, particularly HER2, have dramatically improved patie...

詳細記述

保存先:
書誌詳細
出版年:Nat Chem Biol
主要な著者: Novotny, Chris J., Pollari, Sirkku, Park, Jin H., Lemmon, Mark A., Shen, Weijun, Shokat, Kevan M.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069157/
https://ncbi.nlm.nih.gov/pubmed/27595329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2171
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