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Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding
The heterodimeric receptor tyrosine kinase complex formed by HER2 and HER3 can act as an oncogenic driver and is also responsible for rescuing a large number of cancers from a diverse set of targeted therapies. Current inhibitors of these proteins, particularly HER2, have dramatically improved patie...
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| 出版年: | Nat Chem Biol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5069157/ https://ncbi.nlm.nih.gov/pubmed/27595329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2171 |
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