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Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates

PURPOSE: Cisplatin, carboplatin, and oxaliplatin are chemically reactive anticancer drugs with modest activity in brain tumors. Previously, we have demonstrated that drug exposure in cerebrospinal fluid (CSF) for these platinum analogs is <5% of the plasma ultrafiltrate (UF) drug exposure in nonh...

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Détails bibliographiques
Publié dans:Cancer Chemother Pharmacol
Auteurs principaux: Jacobs, Shana, McCully, Cynthia L., Murphy, Robert F., Bacher, John, Balis, Frank M., Fox, Elizabeth
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936607/
https://ncbi.nlm.nih.gov/pubmed/19662415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1085-7
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