Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes

Intracerebral hemorrhage (ICH) is a devastating stroke subtype and the presence of extracorpuscular hemoglobin (Hb) exacerbates brain damage. Haptoglobin (Hp) binds Hb, which prevents its oxidation and participation in neurotoxic reactions. Multiple studies have investigated the role of Hp under con...

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Vydáno v:Exp Neurol
Hlavní autoři: Leclerc, Jenna L, Li, Chris, Jean, Stacy, Lampert, Andrew S, Amador, Claudia Loyola, Diller, Matthew A, Tolosano, Emanuela, Doré, Sylvain
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936604/
https://ncbi.nlm.nih.gov/pubmed/30790555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.01.011
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