Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes

Intracerebral hemorrhage (ICH) is a devastating stroke subtype and the presence of extracorpuscular hemoglobin (Hb) exacerbates brain damage. Haptoglobin (Hp) binds Hb, which prevents its oxidation and participation in neurotoxic reactions. Multiple studies have investigated the role of Hp under con...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Leclerc, Jenna L, Li, Chris, Jean, Stacy, Lampert, Andrew S, Amador, Claudia Loyola, Diller, Matthew A, Tolosano, Emanuela, Doré, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936604/
https://ncbi.nlm.nih.gov/pubmed/30790555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.01.011
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