Ly49R activation receptor drives self-MHC–educated NK cell immunity against cytomegalovirus infection

Natural killer (NK) cells mediate vital control of cancer and viral infection. They rely on MHC class I (MHC I)-specific self-receptors to identify and lyse diseased cells without harming self-MHC I-bearing host cells. NK cells bearing inhibitory self-receptors for host MHC I also undergo education,...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gamache, Awndre, Cronk, John M., Nash, William T., Puchalski, Patryk, Gillespie, Alyssa, Wei, Hairong, Gray, Laurie, Hammarskjold, Marie-Louise, Xu, Wenhao, Brown, Michael G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936569/
https://ncbi.nlm.nih.gov/pubmed/31843910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913064117
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