The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors

CMVs efficiently target MHC I molecules to avoid recognition by cytotoxic T cells. However, the lack of MHC I on the cell surface renders the infected cell susceptible to NK cell killing upon missing self recognition. To counter this, mouse CMV (MCMV) rescues some MHC I molecules to engage inhibitor...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Železnjak, Jelena, Lisnić, Vanda Juranić, Popović, Branka, Lisnić, Berislav, Babić, Marina, Halenius, Anne, L’Hernault, Anne, Roviš, Tihana Lenac, Hengel, Hartmut, Erhard, Florian, Redwood, Alec J., Vidal, Silvia M., Dölken, Lars, Krmpotić, Astrid, Jonjić, Stipan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683999/
https://ncbi.nlm.nih.gov/pubmed/31142589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182213
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