Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

BACKGROUND: Compounds in clinical development for nonalcoholic steatohepatitis (NASH) improve liver histopathology in diet-induced obese mouse models of biopsy-confirmed NASH. Since the biopsy section used for histopathological evaluation represents only < 1% of the whole mouse liver, we evaluate...

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Bibliographic Details
Published in:BMC Gastroenterol
Main Authors: Baandrup Kristiansen, Maria Nicoline, Veidal, Sanne Skovgård, Christoffersen, Christina, Feigh, Michael, Vrang, Niels, Roth, Jonathan David, Erickson, Mary, Adorini, Luciano, Jelsing, Jacob
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935483/
https://ncbi.nlm.nih.gov/pubmed/31883514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12876-019-1149-z
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