Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis

AIM: To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis (NASH) in obese mouse models of biopsy-confirmed NASH. METHODS: Male wild-type C57BL/6J mice (DIO-NASH) and Lep(ob/ob) (ob/ob-NASH) mice were fed a diet high in trans-fat (40%), fructose (20%)...

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Podrobná bibliografie
Vydáno v:World J Gastroenterol
Hlavní autoři: Tølbøl, Kirstine S, Kristiansen, Maria NB, Hansen, Henrik H, Veidal, Sanne S, Rigbolt, Kristoffer TG, Gillum, Matthew P, Jelsing, Jacob, Vrang, Niels, Feigh, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2018
Témata:
Basic Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768937/
https://ncbi.nlm.nih.gov/pubmed/29375204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v24.i2.179
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