HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

BACKGROUND: Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Wierenga, Albertus T. J., Cunningham, Alan, Erdem, Ayşegül, Lopera, Nuria Vilaplana, Brouwers-Vos, Annet Z., Pruis, Maurien, Mulder, André B., Günther, Ulrich L., Martens, Joost H. A., Vellenga, Edo, Schuringa, Jan Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935105/
https://ncbi.nlm.nih.gov/pubmed/31890203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-019-0206-y
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