BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9(+) leukemic cells

In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in vivo efficacy of the BRD3/4 inhibitor I-BET151 in...

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Pubblicato in:PLoS One
Autori principali: Carretta, Marco, Brouwers-Vos, Annet Z., Bosman, Matthieu, Horton, Sarah J., Martens, Joost H. A., Vellenga, Edo, Schuringa, Jan Jacob
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730124/
https://ncbi.nlm.nih.gov/pubmed/29240787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189102
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