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Proximal Tubule Translational Profiling during Kidney Fibrosis Reveals Proinflammatory and Long Noncoding RNA Expression Patterns with Sexual Dimorphism

BACKGROUND: Proximal tubule injury can initiate CKD, with progression rates that are approximately 50% faster in males versus females. The precise transcriptional changes in this nephron segment during fibrosis and potential differences between sexes remain undefined. METHODS: We generated mice with...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Wu, Haojia, Lai, Chun-Fu, Chang-Panesso, Monica, Humphreys, Benjamin D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935009/
https://ncbi.nlm.nih.gov/pubmed/31537650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019040337
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