Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

Actomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC. However, the distinct...

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Pubblicato in:Sci Rep
Autori principali: Srinivasan, Srisathya, Das, Sreya, Surve, Vishakha, Srivastava, Ankita, Kumar, Sushant, Jain, Nikita, Sawant, Abhijeet, Nayak, Chitra, Purwar, Rahul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934852/
https://ncbi.nlm.nih.gov/pubmed/31882703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56447-2
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