Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

Actomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC. However, the distinct...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Srinivasan, Srisathya, Das, Sreya, Surve, Vishakha, Srivastava, Ankita, Kumar, Sushant, Jain, Nikita, Sawant, Abhijeet, Nayak, Chitra, Purwar, Rahul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934852/
https://ncbi.nlm.nih.gov/pubmed/31882703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56447-2
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