Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

Actomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC. However, the distinct...

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Publicado no:Sci Rep
Main Authors: Srinivasan, Srisathya, Das, Sreya, Surve, Vishakha, Srivastava, Ankita, Kumar, Sushant, Jain, Nikita, Sawant, Abhijeet, Nayak, Chitra, Purwar, Rahul
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934852/
https://ncbi.nlm.nih.gov/pubmed/31882703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56447-2
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