Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

Actomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC. However, the distinct...

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發表在:Sci Rep
Main Authors: Srinivasan, Srisathya, Das, Sreya, Surve, Vishakha, Srivastava, Ankita, Kumar, Sushant, Jain, Nikita, Sawant, Abhijeet, Nayak, Chitra, Purwar, Rahul
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934852/
https://ncbi.nlm.nih.gov/pubmed/31882703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56447-2
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