Effects of a remote mutation from the contact paratope on the structure of CDR-H3 in the anti-HIV neutralizing antibody PG16

PG16 is a broadly neutralizing antibody to the human immunodeficiency virus (HIV). A crystal structure of PG16 revealed that the unusually long 28-residue complementarity determining region (CDR) H3 forms a unique subdomain, referred to as a “hammerhead”, that directly contacts the antigen. The hamm...

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Vydáno v:Sci Rep
Hlavní autoři: Kondo, Hiroko X., Kiribayashi, Ryo, Kuroda, Daisuke, Kohda, Jiro, Kugimiya, Akimitsu, Nakano, Yasuhisa, Tsumoto, Kouhei, Takano, Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934664/
https://ncbi.nlm.nih.gov/pubmed/31882602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56154-y
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