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A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes

Pediatric patients are at elevated risk of adverse drug reactions, and there is insufficient information on drug safety in children. Complicating risk assessment in children, there are numerous age-dependent changes in the absorption, distribution, metabolism, and elimination of drugs. A key contrib...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Matlock, Matthew K., Tambe, Abhik, Elliott-Higgins, Jack, Hines, Ronald N., Miller, Grover P., Swamidass, S. Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933754/
https://ncbi.nlm.nih.gov/pubmed/31304741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00223
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