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How Electrostatic Coupling Enables Conformational Plasticity in a Tyrosine Kinase
Protein kinases are important cellular signaling molecules involved in cancer and a multitude of other diseases. It is well known that inactive kinases display a remarkable conformational plasticity; however, the molecular mechanisms remain poorly understood. Conformational heterogeneity presents an...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6933753/ https://ncbi.nlm.nih.gov/pubmed/31476863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06064 |
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