l‐tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK‐TRAF6 interactions and inhibiting NF‐κB and MAPK pathways

Bone homeostasis is delicately orchestrated by osteoblasts and osteoclasts. Various pathological bone loss situations result from the overactivated osteoclastogenesis. Receptor activator of nuclear factor κB ligand (RANKL)‐activated NF‐κB and MAPK pathways is vital for osteoclastogenesis. Here, we f...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Zhi, Xin, Wang, Lipeng, Chen, Huiwen, Fang, Chao, Cui, Jin, Hu, Yan, Cao, Liehu, Weng, Weizong, Zhou, Qirong, Qin, Longjuan, Song, Hongyuan, Wang, Yajun, Wang, Yao, Jiang, Hao, Li, Xiaoqun, Wang, Sicheng, Chen, Xiao, Su, Jiacan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933417/
https://ncbi.nlm.nih.gov/pubmed/31725199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14790
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