Array comparative genomic hybridization based identification of key genetic alterations at 2p21-p16.3 (MSH2, MSH6, EPCAM), 3p23-p14.2 (MLH1), 7p22.1 (PMS2) and 1p34.1-p33 (MUTYH) regions in hereditary non polyposis colorectal cancer (Lynch syndrome) in the Kingdom of Saudi Arabia

Lynch syndrome is inherited in an autosomal dominant mode. Lynch syndrome is caused by impairment of one or more of the various genes (most frequently MLH1 and MSH2) involved in mismatch repair. In this study, whole genome comparative genomic hybridization array (array CGH) based genomic analysis wa...

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Udgivet i:Saudi J Biol Sci
Main Authors: Rasool, Mahmood, Pushparaj, Peter Natesan, Mirza, Zeenat, Imran Naseer, Muhammad, Abusamra, Heba, Alquaiti, Maha, Shaabad, Manal, Sibiany, Abdulrahman Mohamed Saeed, Gauthaman, Kalamegam, Al-Qahtani, Mohammed Hussein, Karim, Sajjad
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933242/
https://ncbi.nlm.nih.gov/pubmed/31889830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sjbs.2019.06.012
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