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Steric enforcement of cis-epoxide formation in the radical C–O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces Fosfomycin
(S)-2-hydroxypropylphosphonate [(S)-2-HPP, 1] epoxidase (HppE) reduces H(2)O(2) at its non-heme-iron cofactor to install the oxirane “warhead” of the antibiotic fosfomycin. The net replacement of the C1 pro-R hydrogen of 1 by its C2 oxygen, with inversion of configuration at C1, yields the cis epoxi...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6933072/ https://ncbi.nlm.nih.gov/pubmed/31769979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b10974 |
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