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Steric enforcement of cis-epoxide formation in the radical C–O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces Fosfomycin

(S)-2-hydroxypropylphosphonate [(S)-2-HPP, 1] epoxidase (HppE) reduces H(2)O(2) at its non-heme-iron cofactor to install the oxirane “warhead” of the antibiotic fosfomycin. The net replacement of the C1 pro-R hydrogen of 1 by its C2 oxygen, with inversion of configuration at C1, yields the cis epoxi...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Zhou, Shengbin, Pan, Juan, Davis, Katherine M., Schaperdoth, Irene, Wang, Bo, Boal, Amie K., Krebs, Carsten, Bollinger, J. Martin
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933072/
https://ncbi.nlm.nih.gov/pubmed/31769979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b10974
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