Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo

BACKGROUND AND PURPOSE: Aerobic glycolysis is a unique feature of tumour cells that entails several advantages for cancer progression such as resistance to apoptosis. The low MW compound, dichloroacetate, is a pyruvate dehydrogenase kinase inhibitor, which restores oxidative phosphorylation and indu...

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Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Twarock, Sören, Reichert, Christina, Bach, Katharina, Reiners, Oliver, Kretschmer, Inga, Gorski, Daniel J., Gorges, Katharina, Grandoch, Maria, Fischer, Jens W.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932941/
https://ncbi.nlm.nih.gov/pubmed/31351004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14808
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