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Direct and Indirect Quantification of Phosphate Metabolites of Nucleoside Analogs in Biological Samples
Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs that require intracellular phosphorylation to active triphosphate nucleotide metabolites (NMs) for their pharmacological activity. However, monitoring these pharmacologically active NMs is challenging due to their instability, high hyd...
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| Publicado en: | J Pharm Biomed Anal |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6931899/ https://ncbi.nlm.nih.gov/pubmed/31610397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.112902 |
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