Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

The quinazolines CBR417 and CBR490 were previously shown to be potent anti-wolbachials that deplete Wolbachia endosymbionts of filarial nematodes and present promising pre-clinical candidates for human filarial diseases such as onchocerciasis. In the present study we tested both candidates in two mo...

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Bibliografiset tiedot
Julkaisussa:Int J Parasitol Drugs Drug Resist
Päätekijät: Hübner, Marc P., Gunderson, Emma, Vogel, Ian, Bulman, Christina A., Lim, K.C., Koschel, Marianne, Ehrens, Alexandra, Frohberger, Stefan J., Fendler, Martina, Tricoche, Nancy, Voronin, Denis, Steven, Andrew, Chi, Victor, Bakowski, Malina A., Woods, Ashley K., Petrassi, H. Michael, McNamara, Case W., Beerntsen, Brenda, Chappell, Laura, Sullivan, William, Taylor, Mark J., Turner, Joseph D., Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931063/
https://ncbi.nlm.nih.gov/pubmed/31869759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2019.12.001
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