Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

Capecitabine is an oral prodrug of the anticancer drug 5‐fluorouracil (5‐FU). The primary aim of this study was to develop a pharmacokinetic model for capecitabine and its metabolites, 5′‐deoxy‐5‐fluorocytidine (dFCR), 5′‐deoxy‐5‐fluorouridine (dFUR), 5‐FU, and fluoro‐β‐alanine (FBAL) using data fro...

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Vydáno v:CPT Pharmacometrics Syst Pharmacol
Hlavní autoři: Jacobs, Bart A.W., Deenen, Maarten J., Joerger, Markus, Rosing, Hilde, de Vries, Niels, Meulendijks, Didier, Cats, Annemieke, Beijnen, Jos H., Schellens, Jan H.M., Huitema, Alwin D.R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930859/
https://ncbi.nlm.nih.gov/pubmed/31652031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12474
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