Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations

As there are increased levels and activity of butyrylcholiesterase (BChE) in the late stage of Alzheimer’s disease (AD), development of selective BChE inhibitors is of vital importance. In this study, a workflow combining computational technologies and biological assays were implemented to identify...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Zhou, You, Lu, Xin, Yang, Hongyu, Chen, Yao, Wang, Feng, Li, Jifu, Tang, Zhiran, Cheng, Xifei, Yang, Yingbin, Xu, Li, Xia, Qingyou
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930573/
https://ncbi.nlm.nih.gov/pubmed/31757047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24234217
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