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Model of Human Butyrylcholinesterase (BChE) Tetramer by Homology Modeling and Dynamics Simulation

A mutant of human butyrylcholinesterase (BChE) with high activity against cocaine would be highly promising as a drug for therapeutic treatment of cocaine abuse and overdose. It is desirable to design a recombinant BChE mutant with a long half-life in human circulation. Studies showed that BChE subu...

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Main Authors: Pan, Yongmei, Muzyka, Jennifer L., Zhan, Chang-Guo
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755204/
https://ncbi.nlm.nih.gov/pubmed/19402731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp8114995
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