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Integrin-mediated Signaling via Paxillin-GIT1-PIX Promotes Localized Rac Activation at the Leading Edge and Cell Migration

Rac activation is precisely regulated temporally and spatially by intracellular signaling pathways in migrating cells to guarantee the formation of specific cell protrusions-lamellipodia at the leading edge. Integrins-mediated adhesions also control the signaling pathway for localized Rac activation...

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Dettagli Bibliografici
Pubblicato in:J Cancer
Autori principali: Li, Youjun, Wu, Xinzhou, Liu, Zhiqiang, Lu, Kanghui, Liu, Rushi, Guo, Xiangrong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930425/
https://ncbi.nlm.nih.gov/pubmed/31897230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.32853
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