Paxillin phosphorylation at Ser273 localizes a GIT1–PIX–PAK complex and regulates adhesion and protrusion dynamics

Continuous adhesion formation and disassembly (adhesion turnover) in the protrusions of migrating cells is regulated by unclear mechanisms. We show that p21-activated kinase (PAK)–induced phosphorylation of serine 273 in paxillin is a critical regulator of this turnover. Paxillin-S273 phosphorylatio...

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Autors principals: Nayal, Anjana, Webb, Donna J., Brown, Claire M., Schaefer, Erik M., Vicente-Manzanares, Miguel, Horwitz, Alan Rick
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063867/
https://ncbi.nlm.nih.gov/pubmed/16717130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200509075
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