Implementing Efficient Peptoid‐Mediated Delivery of RNA‐Based Therapeutics to the Vocal Folds

OBJECTIVE: We hypothesize that Smad3 is a master regulator of fibrosis in the vocal folds (VFs) and RNA‐based therapeutics targeting Smad3 hold therapeutic promise. Delivery remains challenging. We previously described a novel synthetic peptoid oligomer, lipitoid L0, complexed with siRNA to improve...

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Bibliografische gegevens
Gepubliceerd in:Laryngoscope Investig Otolaryngol
Hoofdauteurs: Mukudai, Shigeyuki, Kraja, Iv, Bing, Renjie, Nalband, Danielle M., Tatikola, Mallika, Hiwatashi, Nao, Kirshenbaum, Kent, Branski, Ryan C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2019
Onderwerpen:
LARYNGOLOGY, SPEECH AND LANGUAGE SCIENCE
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929602/
https://ncbi.nlm.nih.gov/pubmed/31890882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lio2.310
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