CD4(+) T cell help is required for the formation of a cytolytic CD8(+) T cell subset that protects against chronic infection and cancer

Although CD4(+) T cell “help” is crucial to sustain antiviral immunity, the mechanisms by which CD4(+) T cells regulate CD8(+) T cell differentiation during chronic infection remain elusive. Here, using single-cell RNA-sequencing we show that CD8(+) T cells responding to chronic infection were more...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Zander, Ryan, Schauder, David, Xin, Gang, Nguyen, Christine, Wu, Xiaopeng, Zajac, Allan, Cui, Weiguo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929322/
https://ncbi.nlm.nih.gov/pubmed/31810883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.10.009
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