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CD4(+) T cell help is required for the formation of a cytolytic CD8(+) T cell subset that protects against chronic infection and cancer
Although CD4(+) T cell “help” is crucial to sustain antiviral immunity, the mechanisms by which CD4(+) T cells regulate CD8(+) T cell differentiation during chronic infection remain elusive. Here, using single-cell RNA-sequencing we show that CD8(+) T cells responding to chronic infection were more...
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| Publicado no: | Immunity |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6929322/ https://ncbi.nlm.nih.gov/pubmed/31810883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.10.009 |
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