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CD4(+) T cell help is required for the formation of a cytolytic CD8(+) T cell subset that protects against chronic infection and cancer
Although CD4(+) T cell “help” is crucial to sustain antiviral immunity, the mechanisms by which CD4(+) T cells regulate CD8(+) T cell differentiation during chronic infection remain elusive. Here, using single-cell RNA-sequencing we show that CD8(+) T cells responding to chronic infection were more...
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| Publicat a: | Immunity |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6929322/ https://ncbi.nlm.nih.gov/pubmed/31810883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.10.009 |
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