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Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified yet Important Action

Roxadustat (FG-4592), an analog of 2-oxoglutarate, is an orally-administered, heterocyclic small molecule known to be an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase. However, none of the studies have thus far thoroughly investigated its possible perturbations on membrane ion curre...

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Foilsithe in:Int J Mol Sci
Main Authors: Chang, Wei-Ting, Lo, Yi-Ching, Gao, Zi-Han, Wu, Sheng-Nan
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928729/
https://ncbi.nlm.nih.gov/pubmed/31795416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20236027
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