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Identification of Novel PI3Kδ Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations

Phosphoinositide 3 kinase delta (PI3Kδ) is a lipid kinase that has been implicated in a variety of immune mediated disorders. The research on isoform selectivity was crucial for reducing side effects. In the current study, an optimized hierarchical multistage virtual screening method was utilized fo...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Liang, Jing-wei, Wang, Shan, Wang, Ming-yang, Li, Shi-long, Li, Wan-qiu, Meng, Fan-hao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928688/
https://ncbi.nlm.nih.gov/pubmed/31795217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20236000
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