טוען...
Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models
Serine hydroxymethyltransferases (SHMTs) reversibly transform serine into glycine in a reaction accompanied with conversion of tetrahydrofolate (THF) into 5,10-methylene-THF (5,10-meTHF). In vivo, 5,10-meTHF is the main carrier of one-carbon (1C) units, which are utilized for nucleotide biosynthesis...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6928210/ https://ncbi.nlm.nih.gov/pubmed/31873125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56043-4 |
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