Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

Serine hydroxymethyltransferases (SHMTs) reversibly transform serine into glycine in a reaction accompanied with conversion of tetrahydrofolate (THF) into 5,10-methylene-THF (5,10-meTHF). In vivo, 5,10-meTHF is the main carrier of one-carbon (1C) units, which are utilized for nucleotide biosynthesis...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Ruszkowski, Milosz, Sekula, Bartosz, Ruszkowska, Agnieszka, Contestabile, Roberto, Nogues, Isabel, Angelaccio, Sebastiana, Szczepaniak, Andrzej, Dauter, Zbigniew
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928210/
https://ncbi.nlm.nih.gov/pubmed/31873125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56043-4
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