SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

Growth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate appropriate foliation and lobule formation. Indee...

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Udgivet i:Sci Rep
Main Authors: Petroni, Marialaura, Sahùn Roncero, Maria, Ramponi, Valentina, Fabretti, Francesca, Nicolis Di Robilant, Vittoria, Moretti, Marta, Alfano, Vincenzo, Corsi, Alessandro, De Panfilis, Simone, Giubettini, Maria, Di Giulio, Stefano, Capalbo, Carlo, Belardinilli, Francesca, Coppa, Anna, Sardina, Francesca, Colicchia, Valeria, Pedretti, Flaminia, Infante, Paola, Cardinali, Beatrice, Tessitore, Alessandra, Canettieri, Gianluca, De Smaele, Enrico, Giannini, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928071/
https://ncbi.nlm.nih.gov/pubmed/31873117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56057-y
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