CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy

Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I. In addition to mediating bacterial tropism for neurons, PGL-I interacts with Complement Receptor (CR)3 on macrophages (MPs) to promote...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Immunol
Päätekijät: Doz-Deblauwe, Émilie, Carreras, Florence, Arbues, Ainhoa, Remot, Aude, Epardaud, Mathieu, Malaga, Wladimir, Mayau, Véronique, Prandi, Jacques, Astarie-Dequeker, Catherine, Guilhot, Christophe, Demangel, Caroline, Winter, Nathalie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Immunology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928039/
https://ncbi.nlm.nih.gov/pubmed/31921172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02913
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