CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy

Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I. In addition to mediating bacterial tropism for neurons, PGL-I interacts with Complement Receptor (CR)3 on macrophages (MPs) to promote...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Doz-Deblauwe, Émilie, Carreras, Florence, Arbues, Ainhoa, Remot, Aude, Epardaud, Mathieu, Malaga, Wladimir, Mayau, Véronique, Prandi, Jacques, Astarie-Dequeker, Catherine, Guilhot, Christophe, Demangel, Caroline, Winter, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928039/
https://ncbi.nlm.nih.gov/pubmed/31921172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02913
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