Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

Phenolic glycolipids (PGLs) are cell wall components of a subset of pathogenic mycobacteria, with immunomodulatory properties. Here, we show that in addition, PGLs exert antibactericidal activity by limiting the production of nitric oxide synthase (iNOS) in mycobacteria-infected macrophages. PGL-med...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Oldenburg, Reid, Mayau, Veronique, Prandi, Jacques, Arbues, Ainhoa, Astarie-Dequeker, Catherine, Guilhot, Christophe, Werts, Catherine, Winter, Nathalie, Demangel, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780341/
https://ncbi.nlm.nih.gov/pubmed/29403489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00002
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